This work aims to elaborate on the current situation of tissue engineering in the context of hereditary skin diseases, with special attention to the recessive dystrophic epidermolysis bullosa (RDEB). Here, epidermolysis bullosa is studied in detail and possible molecular and stem cell therapies are discussed. To start, the origin and derivation of embryonic and adult stem cells is explained. A revolutionary milestone in the biomedical field was the discovery of how differentiated somatic cells can be reprogrammed into pluripotent stem cell state. The methods and potential for this procedure are also mentioned here. In order to use these cells therapeutically, subsequently, they must be repaired by gene manipulation. The illustration how this can work is a part of this thesis. Regenerative medicine is gaining in importance and it is a very promising area for the restoration of destroyed or damaged the body's own tissues. Currently new available technologies and manufacturing processes for the development of artificial skin are listed. In conclusion it will be discussed if a tailored to the patient's personalized medicine could be sometimes possible.