Humor is a component of the human experience and is known for its versatile, complex, spontaneous, unexpected and individual character. This phenomenon is experienced by nurses and patients in their daily clinical routine. Since the year 1990 the therapeutic use of humor in healthcare and nursing has gained more interest. It plays a significant role in helping breast cancer patients to deal with their sickness. These patients are confronted with unbearable and agonizing side effects of their sickness, which influence the body and mind. This paper examines the meanings and influences of humor in female breast cancer patients and nurses. In addition, the practical use of this phenomenon in the daily nursing routine is illustrated. The results imply, that humor is used by women with breast cancer as a coping-mechanism to adapt to difficult of stressful experiences. Humor helps the women to adjust to negative emotions and learn how to relax. The relationship and trust between the nurses and the women is strengthened by humor. However, humor has negative effects to, which is demonstrated by using black or grim humor. There are many ways how to use the therapeutic effects of humor in the practical routine of nursing. In this sense, humor is used as an individual specific practical action to help women cope with their sickness.