Our modern and western society is witnessing increasing numbers of immigration. Nowadays, people with immigrant background are granted professional medical care, including palliative care. The discipline of palliative care focuses on the basic needs and wishes of the patients, which people with migration backgrounds should receive as well. Unfortunately many nurses are unfamiliar with all the different cultural and religious behavioral patterns, which cause prejudice and misunderstandings. Palliative Nurses are confronted with new ethical demands. In order to provide good quality care at the end of life, it is important for nurses to obtain cultural competences and transcultural nursing principles. To understand specific factors, it is important to reflect on one’s environment and point of views in order to understand one’s own culture. This motivates the health care providers to observe what needs and wishes the patients have. The nurses should always maintain an open mind and conscience regarding new cultures and people. It is important to appreciate each person’s unique backgrounds. Putting effort in using the transcultural nursing principles, patients with migration background are granted a fulfilled and respectful end of life care.