Preterm infants are considered as a vulnerable group of patients, who have unfavorable starting conditions because of the untimely birth. Its stay on a neonatal intensive care unit is a heavy burden for the immature babies since they are exposed to many disturbing factors and to an overflow of intensive, unnatural stimuli. To bare with such a situation is not only a hard and challenging circumstance for the baby, but also parents feel powerless at the mercy of their broken expectations, the early seperation and the transfer of their responsibility for the preterm baby to the treatment team. By means of developmental care, opportunities are given to the nurses to ensure an individually customized caregiving, which is also suitable for these unique children, and to eliminate feelings of pain and stress, so that the prematurely born child can develop in an unimpeded manner. A high level of well-being and healthy developing can be achieved by tender care, empathic attention and skin-to-skin contact of their attachment person. Furthermore, this care concept makes a sensitive accompaniment and support of parents possible and allows to involve them in the course of therapy, so that the buildup of a parent-child relationship can take place in a pleasant atmosphere. The basis of development-promoting care is the willingness of nurses to get in touch with the preterm infant as well as the expertise to observe the smallest responses and reactions of the little patient, to unterstand them and to embrace the ressources of the prematurely born infant in order to bring offers of support and nursing actions with those in line. The aim of this work is to increase the importance and the awareness of pain and stress relieving measures in nursing professionals in the care of premature infants and to express the promising, affirmative facets of this sensitive work area.