The stigmatisation and discrimination of mentally ill people by professions is still being practised in treatment- and care- systems that are dominated by biomedical models of illness. This research paper deals with the taboo topic of stigmatisation and discrimination by professions in the bio-psycho-social field. A special emphasis will be placed on the role of social work. The negative effects of stigmatisation and discrimination towards mentally ill people are poignantly manifested in the mutually dependent medical-psychological and social spheres of the lives of those affected. Regarding the literature about stigmatisation and discrimination by professions it becomes clearly evident that, despite the reforms made during the past century, a biomedical perspective is still prevailing, particularly in the area of severe mental illnesses/psychiatric disorders. Accompanying this perspective are professional stances and framework conditions that are fostering discrimination and stigmatisation. This paper first and foremost demonstrates that social work as a profession plays a pivotal role in this area. Namely as part of the current situation - in which increased emancipation and lobbying work would be required from the social work area – and also as a profession that is, or can potentially be part of a new reform of the psychiatric treatment and care, involving the further development of new approaches, models and paradigms, that leaves little or even no room for stigmatisation and discrimination by professions.