This thesis deals with the comparison of two non invasive stress tests, which are used to diagnose coronary artery disease. It focuses on bicycle stress test (ergometry) and myocardial perfusion scintigraphy. These two represent standard procedures in the clinical practice at the Vienna General Hospital. On the one hand, this thesis will handle the impact of gender on the accuracy of the methods. On the other hand, it will compare the implementations of the methods, the working process, the method’s characteristics and imaging scope and the significance of their results to diagnose coronary artery disease. To achieve these goals, a retrospective analysis was performed, in which the results of the two stress tests were related to the gold-standard method which is coronary angiography. The total population included 878 patients. 20 patients had an ergometry and a coronary angiography and 142 had a scintigraphy and a coronary angiography. Of the 20 patients with a positive ergometry, coronary angiography confirmed coronary artery disease in 70% and rejected the diagnosis in 30%. Of the 142 patients diagnosed positive by myocardial scintigraphy, coronary angiography confirmed coronary artery diseas in 78,2% and rejected the diagnosis in 21,8%. Confidence intervals of these two stress tests were compared with each other, which shows an overlap of the confidence intervals. This means, that at the Vienna General Hospital the ergometry as well as the myocardial perfusion scintigraphy are at the same level to diagnose the coronary artery disease. In addition this thesis compared the impact of gender on these two screening methods. It is well known, that women, who suffer from coronary artery disease show different symptoms under exercise than men. During ergometry women show among others decreased systolic blood pressure and heart index. If women have to do myocardial perfusion scintigraphy, the biomedical analytic needs to consider the chest circumference of the patient. Patients with a big chest circumference can falsify the results of a thallium scintigraphy, wherefore the physician needs to inject technetium.