This thesis deals with cross-reactivity between birch pollen and homologues proteins. This cross-allergy leads to a birch pollen-related food allergy. One of the main symptoms is itching of the tongue and is called oral allergy syndrome. Other possible symptoms that may occur are rhinoconjunctivitis and anaphylactic reactions. The first step in the diagnosis of the birch pollen related food allergy is the clinical history, which is very characteristic. Usually no other tests are done to diagnose this kind of allergy. But to perform investigation one can use the skin prick test, measuring of allergen-specific IgE or perform the oral provocation test. Another promising method is the basophil activation test.
The only way of causative treatment of allergies is allergen-specific immunotherapy. There are some routes for immunotherapy. The most common therapy routes are subcutaneous, sublingual and oral. Studies investigating the effect of birch pollen-specific immunotherapy on the associated food allergy reported mixed results. Some of the investigators reported a reduction of the associated food allergy, while others describe limited benefits. So the results are equivocal. It is not possible to compare the investigations, because the used methods are different. There is still an need for standardized investigations in this matter.