A substantial problem in the in-patient care of persons with mental illnesses is the emergence of crises, which can occur more easily due to the mental disorders themselves as well as because of the unusual situation of the hospitalization and of the treatment process. These crises can represent an imminent risk for the patient and his/her environment and have serious consequences. This work will reflect possibilities of intervention which build on the work on the nurse-patient relationship. This relationship, in the inpatient psychiatry, is not only a frame for care but an element of the therapy in itself. This therapeutic relationship enables working on the restoration and development of social and personal abilities of patients, as well as on the learning of self-help, of coping and of a problem-solving approach. Care concepts such as interpersonal relations by Peplau and person-centered care will be examinated here, as well as the application of further competences, which are useful for the therapeutic relationship and are confirmed in their efficiency by various studies.