These thesis deals with the challenges arising from the intercultural care situation for the health care and nursing staff at the intensive care unit. Thus, challenges arise in the care of patients with a background of migration in communication, care, dealing with relatives and the event of dying and death. It is also visible that culture is very influential in understanding the disease and dealing with pain. As a result, opportunities are sought, how the health care and nursing staff at the intensive care unit, can deal effectively with this situation. The theory about culture-specific care of Madeleine Leininger, as well as practice-oriented methods for the development of transcultural competence, are mentioned as possibilities to cope with these challenges at the intensive care unit, resulting by patients of different cultures.