Today, violence and aggression are present in all areas of our lives. The field of professional health and medical care is not an exception. Numerous international and national studies outline a high prevalence of both phenomena, with psychiatry, emergency care and long-term care being the most affected departments. Whether deeds are performed by the nurses against the patients, between the patients in need of care, or also by patients to nurses, both subjects point to a complex occurrence. In terms of patient aggressions against professional caregivers, the consequences of such situations are difficult to overcome by the victims. Mental stress, physical injuries and social impairments are only some of the possible negative effects that may occur. In this case, the leaders play a significant role in responding professionally to violence, aggression and aftercare of victims. According to their duties and responsibilities as leaders, they are obliged to ensure the safety of all actors involved in the care process. This implies that they must take the necessary and appropriate measures to actively participate in the successful prevention of violence and aggression. To this end, they have a broad range of measures and instruments are at their disposal, so as to help prevent further dangerous conflicts.