In nursing, severe occupational stress may associate with pain syndromes. The subjective experience by nurses with chronic pain has not found sufficient attention. This paper aims to analyse the significance on nursing of chronic pain by exploring perceptions of affected nurses in an acute hospital setting. Interventions and strategies by nursing managers are to be reviewed, aiming to support nurses with chronic pain and their ability to work. A first theoretical part covered the scientific background. The second empirical part described a study that used a descriptive qualitative design. Seven semi-structured interviews were performed with nurses suffering from chronic pain and evaluated by qualitative content analysis according to Mayring. Four main inductive categories were developed from the interviews: “Nursing work“; “Personal implications and coping strategies“; “Role of workplace“; and ”Role of nursing team and nursing management“. Chronic pain during nursing was always a burden and challenge, and work performance by all interviewees was impaired. In addition to physical and mental affliction, cognition and emotions were affected as well. As with pain sufferers in general, individual attitudes were crucial for appropriate coping. The nursing management is challenged to provide appropriate work settings for, to pay individual respect to, and to extend targeted preventive and therapeutic services for, nurses with chronic pain.